Pathophysiology

Transient Ischemic Attack (TIA) is a temporary period of neurological dysfunction caused by a brief interruption in the blood supply to part of the brain. This interruption is usually due to a blood clot or atherosclerosis. Unlike a stroke, TIA does not cause permanent brain damage. However, it is a warning sign that an individual is at risk for a future stroke. The reduction in blood flow during a TIA is transient, typically lasting less than an hour, and symptoms resolve completely.

Medical Diagnosis

Clinical Evaluation
Patient History: Detailed account of the episode, including onset, duration, and resolution of symptoms. Identifying risk factors such as hypertension, diabetes, smoking, and previous cardiovascular events.
Physical Examination: Neurological assessment to evaluate any residual deficits and cardiovascular examination to detect sources of emboli.

Imaging Studies
CT Scan: Initial imaging to rule out hemorrhage or other structural abnormalities.
MRI: More sensitive than CT for detecting ischemic changes and identifying the area affected by the TIA.
Carotid Ultrasound: To assess for carotid artery stenosis or other vascular abnormalities.
Echocardiogram: To evaluate cardiac function and detect sources of emboli.
Angiography: Used selectively to visualize blood vessels and identify stenosis or occlusions.

Signs and Symptoms

Sudden weakness or numbness in the face, arm, or leg, typically on one side of the body.
Sudden confusion, trouble speaking, or difficulty understanding speech.
Sudden trouble seeing in one or both eyes.
Sudden trouble walking, dizziness, loss of balance, or lack of coordination.
Sudden severe headache with no known cause.

Treatment

Immediate management and long-term strategies to prevent future strokes:
Antiplatelet Therapy: Aspirin or clopidogrel to reduce the risk of clot formation.
Anticoagulation: Warfarin or direct oral anticoagulants (DOACs) for patients with atrial fibrillation or other conditions predisposing to embolism.
Blood Pressure Control: Antihypertensive medications to manage hypertension and reduce stroke risk.
Cholesterol Management: Statins or other lipid-lowering agents to manage dyslipidemia.
Lifestyle Modifications: Smoking cessation, regular physical activity, healthy diet, and weight management.
Carotid Endarterectomy: Surgical procedure for significant carotid artery stenosis to prevent future TIAs or strokes.
Diabetes Management: Strict glucose control in patients with diabetes to reduce vascular complications.